Interview with Dr. Jessica Mason

Welcome to a special episode of the Brown Emergency Medicine Podcast. In this episode, we have the pleasure of hearing from Dr. Jessica Mason in an interview conducted by Brown EM resident Dr. Jessie Werner.

Dr. Mason speaks with us regarding her career as an Emergency Medicine physician and renowned educator. She describes how she got her start with podcasting with her series ‘Med Forum’ and how she expanded her reach to not only physicians with ‘EM:RAP’ and ‘Resident Call Room,’ but also to non-physicians with her series ‘This Won’t Hurt a Bit.’

Listen Now:

JessMasonMD.jpeg

Jessica Mason, MD

Assistant Clinical Professor, Department of Emergency Medicine, UCSF Fresno

Dr. Mason is an Assistant Clinical Professor at UCSF Fresno and is the fellowship director of the Emergency Medicine Medical Education fellowship. She is the Deputy Editor of EM:RAP and the Managing Editor of EM:RAP C3, EM:RAP HD, EM:RAP Live, and EM:RAP C3. She is also a co-host and writer for the podcast series ‘This Won’t Hurt a Bit.’

Special thanks to Dr. Jessica Mason for her mentorship in creating this podcast and for her ongoing dedication to medical education.


Catch our other interviews and other new series on our new Brown EM Podcast iTunes stream. Subscribe here!

AEM Education and Training 12: Attitudes, Behavior, and Comfort of Emergency Medicine Residents in Caring for LGBT Patients: What do we know?

Welcome to the twelfth episode of AEM Education and Training, a podcast collaboration between the Academic Emergency Medicine E&T Journal and Brown Emergency Medicine. Each quarter, we'll give you digital open access to AEM E&T Articles or Articles in Press, with an author interview podcast and links to curated supportive educational materials for EM learners and medical educators.

Find this podcast series on iTunes here.

DISCUSSING (CLICK ON TITLE TO ACCESS):

Attitudes, Behavior, and Comfort of Emergency Medicine Residents in Caring for LGBT Patients: What Do We Know? Joel Moll MD, Paul Krieger MD, Sheryl L. Heron MD MPH, Cara Joyce PhD, Lisa Moreno‐Walton MD

LISTEN NOW: INTERVIEW WITH FIRST AUTHOR Joel Moll, MD, FACEP

Joel Moll, MD, FACEP

Residency Program Director

Associate Professor

Department of Emergency Medicine

Virginia Commonwealth University School of Medicine

Abstract

Background

Although lesbian, gay, bisexual, and transgender (LGBT) patients are ubiquitous in emergency medicine (EM), little education is provided to EM physicians on LGBT health care needs and disparities. There is also limited information on EM physician behavior, comfort, and attitudes toward LGBT patients. The objective of this study was to assess EM residents behavior, comfort, and attitudes in LGBT health.

Methods

An anonymous survey link was sent to EM programs via the Council of Residency Director listserv. The primary outcome of the 24‐item descriptive survey was the self‐reported comfort levels and self‐reported practice in LGBT health care. Secondary outcomes included individual comfort toward LGBT colleagues and patients who are LGBT, and the frequency of colleagues making discriminatory statements toward LGBT patients and staff in the emergency department setting. Associations between personal and program demographics and survey responses were also examined.

Results

There were 319 responses The majority of respondents were male (63.4%), Caucasian (69.1%), and heterosexual (92.4%). A sizeable minority of respondents felt histories and physical examinations were more challenging for lesbian, gay, or bisexual patients (24.6%) and more so for transgender patients (42.6%). Most residents do not ask patients to identify sexual orientation when presenting with abdominal or genital complaints (63%). Discriminatory LGBT comments were reported from both fellow residents (16.6%) and faculty (10%). A total of 2.5% of respondents were uncomfortable with other LGBT physicians, and 6% did not agree that LGBT patients deserve the same quality care as others.

Conclusion

A number of residents find caring for LGBT patients more challenging than heterosexual patients. Even with professed comfort with LGBT health care, most residents report taking incomplete sexual histories that may affect patient care. Attitudes toward LGBT patients are mainly, but not completely, positive in this cohort.

Feeling Faint: Reflex Syncope

Case

The patient is 70-year-old female presenting with an episode of loss of consciousness at home. While eating dinner with her husband, the patient stated, “I don’t feel well,” and subsequently lost consciousness for 15 seconds. Per her husband, she spontaneously returned to baseline and vomited once. The patient denied any preceding symptoms including chest pain, shortness of breath, dizziness, nausea. There was no seizure-like activity. She stated that this has occurred 5-6 times previously, but she has had unremarkable Holter monitoring.

She has stable vital signs with a normal physical exam. Her symptoms are not reproducible upon sitting or standing. Laboratory testing, including CBC, BMP, troponin, D-Dimer, and urinalysis, are all within normal limits.  A routine EKG demonstrates normal sinus rhythm with mild PR prolongation and no acute ST changes.

While discussing disposition, the patient states she feels unwell and develops sinus bradycardia on telemetry. Without complete loss of consciousness, she returns to her baseline after 20 seconds. Repeat EKG demonstrates rebound sinus tachycardia without any ischemic or interval changes. She is admitted to cardiology for further monitoring.

While admitted, the patient has an uneventful hospital course. Her echocardiogram demonstrates an ejection fraction of 70% with no underlying structural heart defects. Serial troponins and EKG trending is unremarkable. She tolerates a trial of metoprolol 25mg BID and is discharged home with instructions to follow up for tilt testing.

Diagnosis: Reflex Syncope

Syncope: A transient loss of consciousness with spontaneous return to baseline

Reflex syncope, or neurally-mediated syncope, is thought to present in three ways:

  1. Vasodepressive- primary loss of sympathetic function, presenting as hypotension (1)

  2. Cardioinhibitory- increased parasympathetic function, presenting as bradycardia or asystole (1)

  3. Mixed type- The majority of reflex syncope is mixed (1)

Reflex syncope is thought to result from a trigger causing orthostasis, decreased venous return, thereby decreased cardiac output, and a transient lack of cerebral perfusion inducing transient loss of consciousness. (2)

Syncope can be vasovagal, during high emotional states, or situational, such as post-micturition, while eating, coughing, sneezing, and post-exercise. Carotid sinus syncope and atypical forms, without trigger or prodromes, can also be forms of reflex syncope.(3) It is important to distinguish reflex syncope from other causes of syncope, such as arrhythmogenic or ischemic, orthostatic syncope, and non-syncopal mimics such as stroke, seizure, hemorrhage, etc.(3) Patient history can help guide this differentiation.

 

Demographics

Approximately 40% population have had one or more episodes of syncope. Reflex syncope is the most common type of syncope in any age group; it has been suggested that it may follow a bimodal age distribution.(1) Atypical reflex syncope, without trigger or cause, is more common amongst older patients. However, the rate of cardiac syncope also rises with age and elderly patients are more likely to have concomitant cardiovascular disease or orthostasis induced by medication.(4)

Prognosis

Reflex syncope is generally considered benign and portends a low risk of mortality. However, frequent episodes, particularly in the elderly may predispose to trauma and injury. These patients may benefit from treatment. Researchers have concluded that the number of events in the preceding year is a better predictor of recurrent syncope rather than the total number of lifetime events.(5)

Treatment

The mainstay of treatment is the of avoidance of triggers. Other non-pharmacologic therapies may also help, such as volume support, from increased fluid intake or a high-salt diet, compression shorts or stockings to support venous return, counter-pressure maneuvers, and tilt training.(4) Counter pressure maneuvers are exercises such as muscle tensing, grip squeezing, leg crossing, squatting, bending forward. Patients can try these maneuvers when they feel a prodrome. Ideally this delays symptoms until patients can lay supine, improving venous return and delaying or preventing syncope.(6) The PC trial investigated this in 2006 and showed a lower recurrence of syncope 31.6% compared to 50.9% at 14 months using counter pressure.(7) However, the ISSUE 3 trial demonstrated no difference in syncope prevention between groups.(6) Given the low cost and low risk associated with these maneuvers with the potential for benefit, patients can try these.

A tilt test can be used to reproduce symptoms in patients whom the cause of syncope is less clear. Patients follow a protocol which is dependent upon steep tilting, with additional provocative medications such as isoproterenol or nitroglycerin as needed. Results are interpreted by patient response, vital sign measurements, and timing of symptoms. While there a high sensitivity is reported, it is at the cost of lowered specificity and many false positives. Additionally, patient assignment is important because factors such as home medications and structural heart disease may impact findings. If positive, it may help guide treatment.(8)

Similarly, it has been suggested that patients can perform tilt training as treatment. First discussed in 1998, tilt training consists of in-hospital sessions of suspended tilting, followed by at home training of standing against a wall for several minutes several times per day. While a meta-analysis has suggested benefit to tilt training, this was not sustained when evaluating only randomized studies. Patient noncompliance can also negatively impact outcomes, and lessen efficacy.(6)

Several medications have been proposed to lessen reflex syncope recurrence including: beta blocker, alpha adrenergic, SSRI, fludrocortisone, and theophylline. Many of these have small data sets of evidence or fail to succeed over placebo and are not routinely recommended.(6)

Since our patient was started on metoprolol, we will examine this more specifically. Physiologically, beta blockers are theorized to reduce overall sympathetic response and prevent vagal “overshooting”.(1) While observational data showed promise, many randomized trials have thus far failed to show benefit in decreasing syncope recurrence over placebo.(4)

The data to support beta blockade is largely driven by the POST trial. While initial study results demonstrated no benefit, a subset analysis of adults >42 years old demonstrated improvement with beta blockers in older patients.(9) Two smaller studies by Natale and Leor also showed an age-related distribution of benefit.(9) A randomized prospective trial, POST 5, is currently underway to further examine this conclusion. Results are expected December 2020.(10) As of the 2018 European Society of Cardiology guidelines, beta blockers are not currently routinely supported.(3) Given upcoming trial results these recommendations may change in the future.

Take Away Summary

  • Reflex syncope, or neurally-mediated syncope can be cardioinhibitory, vasodepressive, or mixed

  • Nonpharmacologic interventions such as counter pressure or tilt training may be beneficial for some patients

  • Pharmacologic interventions are broad; beta blockade has shown some initial promise in a subset of older patients, but is not yet routinely recommended across the board

  • Reflex syncope is in general benign, but patients at high risk of trauma or injury may benefit from further care. Young, healthy patients can be given reassurance of a good prognosis. 

Faculty Reviewer: Dr. Kristina McAteer

References

  1. Aydin, M. A., Salukhe, T. V., Wilke, I., & Willems, S. (2010, October 26). Management and therapy of vasovagal syncope: A review. Retrieved May 21, 2019, from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2998831/

  2. Brignole, M., MD. (2016, July 5). Finally, A Drug That Proves to Be Effective Against Vasovagal Syncope! But Not in All Patients. Retrieved May 19, 2019, from http://www.onlinejacc.org/content/accj/68/1/10.full.pdf

  3. Brignole, M., Moya, A., De Lange, F. J., Deharo, J. C., Elliot, P. M., Fanciulli, A., . . . Van Dijk, J. (2018, March 19). 2018 ESC Guidelines for the diagnosis and management of syncope. Retrieved May 21, 2019, from https://academic.oup.com/eurheartj/article/39/21/1883/4939241#13420039

  4. Benditt, D. (n.d.). Reflex syncope in adults and adolescents: Clinical presentation and diagnostic evaluation. Retrieved May 21, 2019, from https://www.uptodate.com/contents/reflex-syncope-in-adults-and-adolescents-clinical-presentation-and-diagnostic-evaluation?search=vasodepressor syncope&source=search_result&selectedTitle=1~84&usage_type=default&display_rank=1

  5. Sumner, G. L., Rose, M. S., Koshman, M. L., Ritchie, D., Sheldon, R. S., & Prevention, I. N. (2010, December). Recent history of vasovagal syncope in a young, referral-based population is a stronger predictor of recurrent syncope than lifetime syncope burden. Retrieved May 21, 2019, from https://www.ncbi.nlm.nih.gov/pubmed?term=20662990

  6. Ravielle, A. (2017, August 09). Update on treatment strategies for vasovagal syncope. Retrieved May 21, 2019, from https://cardiacrhythmnews.com/update-treatment-strategies-vasovagal-syncope/

  7. Van Dijk, N., Quartieri, F., Blanc, J., Garcia-Civera, R., Brignole, M., Moya, A., & Wieling, W. (2006, October 17). Effectiveness of physical counterpressure maneuvers in preventing vasovagal syncope: The Physical Counterpressure Manoeuvres Trial (PC-Trial). Retrieved May 21, 2019, from https://www.ncbi.nlm.nih.gov/pubmed/17045903

  8. Benditt, D. (n.d.). Upright tilt table testing in the evaluation of syncope. Retrieved May 21, 2019, from https://www.uptodate.com/contents/upright-tilt-table-testing-in-the-evaluation-of-syncope?search=vasodepressor syncope&source=search_result&selectedTitle=4~84&usage_type=default&display_rank=4#H11

  9. Sheldon, R., Morillo, C., Klingenheben, T., Krahn, A., Sheldon, A., & Rose, M. (2012, October 1). Age-Dependent Effect of β-Blockers in Preventing Vasovagal Syncope. Retrieved May 21, 2019, from https://www.ahajournals.org/doi/10.1161/CIRCEP.112.974386

  10.  Assessment of Metoprolol in the Prevention of Vasovagal Syncope in Aging Subjects - Full Text View. (n.d.). Retrieved May 21, 2019, from https://clinicaltrials.gov/ct2/show/NCT02123056